The Uzumaki House may have once proudly resided in its village, but thanks to other countries, that house was destroyed. As Naruto’s mother, Kushina Uzumaki, explained in Chapter 500 of the manga (via Viz), the Uzumaki clan is known for their powerful sealing abilities. However, that incredible power raised the fear of other nations. As a result, in what she calls a period of war, Uzushio, the clan’s former village, is no more and members of the Uzumaki are hunted down and killed. Any survivors of the Uzumaki clan were forced to hide in other villages.
Notably, this is how Naruto integrated as a Konoha native, when his mother was sent to live in Konoha. Surprisingly, the Uzumaki clan lives off of characters other than Naruto. Many fans may already know that Konoha’s Fifth Hokage, Tsunade, has Uzumaki blood in his veins thanks to being the niece of Mito Uzumaki, the wife of the First Hokage. But Naruto’s most shocking relatives come thanks to Karin and Nagato. Their fiery red hair and enormous chakra are deadly gifts, but both characters’ relationship with Uzumaki is revealed in key moments of the series. During the fight against Sasuke and Itachi in Chapter 579, Kabuto confirmed that Karin was a descendant of Uzumaki. And in Episode 253 (via Crunchyroll) of the anime, Tobi confirms Nagato’s ties to the clan while visiting his grave.
https://www.looper.com/728644/what-really-happened-to-the-uzumaki-clan-before-the-events-of-naruto/ What really happened to the Uzumaki clan before the events of Naruto