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Study shows Pfizer COVID-19 vaccine effectiveness declines after six months

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A research revealed on Monday in The Lancet medical journal discovered that the efficacy of the Pfizer-BioNTech COVID-19 vaccine fell beneath 50 p.c after about six months after the second dose.

The Pfizer-funded study discovered that Pfizer’s vaccine was 88 p.c efficient within the first month after full vaccination however dropped to 47 p.c effectiveness at about six months. The vaccine was additionally discovered to be extremely efficient in opposition to the delta variant, which was discovered to be over 90 p.c efficient within the first months earlier than dropping to 53 p.c effectiveness after 4 months.

Researchers decided that the waning immunity needed to do with the period of time since a person was given the second shot somewhat than because of the extremely infectious delta pressure.

“Our outcomes present assist for top effectiveness of [Pfizer-BioNTech COVID-19 vaccine] in opposition to hospital admissions up till round 6 months after being absolutely vaccinated, even within the face of widespread dissemination of the delta variant,” the researchers wrote. “Discount in vaccine effectiveness in opposition to SARS-CoV-2 infections over time might be primarily as a result of waning immunity with time somewhat than the delta variant escaping vaccine safety.”

Safety in opposition to hospital admission remained excessive all through, being 93 p.c efficient as much as six months after administration.

For the research, researchers seemed on the digital information of the Kaiser Permanente Southern California (KPSC) well being care system, taking a look at all of the system’s sufferers ages 12 and up. Researchers checked out 3.4 million individuals within the KPSC well being care system that they studied from December 2020 to final August.

Researchers decided that people absolutely vaccinated with the Pfizer-BioNTech vaccine had an general 73 p.c efficient safety in opposition to COVID-19 an infection and a 90 p.c efficient safety in opposition to COVID-19 associated hospitalization.

“Our outcomes reiterate in a real-world US setting that vaccination with [the Pfizer-BioNTech COVID-19 vaccine] stays a necessary software for stopping COVID-19, particularly COVID-19-associated hospital admissions, attributable to all present variants of concern,” they wrote.

The outcomes of those research reiterate findings from Pfizer and BioNTech that have been launched in July. The preprint research discovered that the vaccine’s effectiveness reached a peak of 96.2 p.c inside two months after the second dose, with the shot’s effectiveness discovered on the time to lower by about 6 proportion factors each two months afterwards.

The outcomes of this research come out simply weeks after the Meals and Drug Administration approved a booster dose of the Pfizer coronavirus vaccine for the aged and people at excessive threat of an infection, with the choice made in mild of earlier knowledge that urged the vaccine efficacy fell after some months.

“We imagine boosters have an vital function to play in addressing the continued menace of this illness, alongside efforts to extend world entry and uptake among the many unvaccinated,” Pfizer CEO Albert Bourla mentioned on the time.

https://thehill.com/coverage/healthcare/575279-study-shows-pfizer-covid-19-vaccine-effectiveness-declines-after-six-months | Research exhibits Pfizer COVID-19 vaccine effectiveness declines after six months

Huynh Nguyen

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