There are many possible reasons why “Spider-Man: No Way Home” does not complete the Sinister Six. At first, the movie seems to adhere to a pretty strict rule of “one major villain per film before Tom Holland Spidey,” and since Tobey Maguire has made three and Andrew Garfield two, that’s pretty much it. . Besides, technically, there’s a sixth villain in the movie, Venom. Uniquely, it’s the reincarnation of Tom Hardy, who was only made aware of Spider-Man’s existence in the post-credits scene of “Venom: Let There Be Carnage.” He continues to exist in his peripheral MCU in the movie “No Way Home”, revealing that he is stuck drunk in a faraway destination and can’t be bothered to find his way to New York first. when he returns to his own reality.
If you refuse to accept Hardy’s brief appearance as the missing piece of the Sinister Six, there are some notable villains from the film who were absent from “No Way Home” – but there are reasons why they don’t appear in the movie. Paul Giamatti noted that Rhino will not appear in “No Way Home”, and Dane DeHaan and James Franco’s version of Green Goblin (or, in Franco’s case, “New Goblin”) could have muddied the waters in a movie that featured Willem Dafoe’s version of the character. Likewise, Tom Hardy’s Venom pretty much means that the version of Topher Grace will be a quirky man, interesting for possibly having revisited that incarnation of that character.
This leaves the MCU Spider-Man’s own game gallery, in which Mysterio (Jake Gyllenhaal) is dead, and Michael Keaton is rumored to reprise the role of Vulture in the upcoming “Morbius”, making his appearance here superfluous.
https://www.looper.com/714805/why-didnt-spider-man-no-way-home-introduce-the-sinister-six/ No Way Home Introducing The Sinister Six?